In vivo bioactivities of food protein-derived peptides – a current review

Daniel JonerDaroit¹, Adriano Brandelli²

Programa de Pós-Graduação em Ambiente e Tecnologias Sustentáveis, Universidade Federal da Fronteira Sul (UFFS), Campus Cerro Largo, Av. Jacob Reinaldo Haupenthal 1580, 97900-000 Cerro Largo, RS, Brazil.

Abstract

A great diversity of biological activities has been attributed to peptides. Despite food proteins are essentially considered as sources of dietary amino acids, bioactive peptides can be released during gastrointestinal transit, food fermentation, food maturation, and through enzymatic bioprocessing in vitro. Specific bioactive peptide databases integrated with predictive proteolytic cleavage of proteins are valuable tools allowing a rapid in silico screening of the bioactive potential of dietary proteins. The range of bioactivities generated by hydrolysis of food proteins include antioxidant, antihypertensive, antidiabetic, immunomodulatory, anticancer, and opioid activities. Some of these bioactivities have been also confirmed in vivo, reinforcing their physiological relevance. This review presents a current perspective on the production and main biological activities of peptides derived from food proteins.